HIV Mother-to-Child Transmission: Pregnancy Outcomes and Serological Status of Newborns of HIV-Positive Mothers Monitored in the Kati Hospital Cohort
Abdoulaye Mamadou TRAORE, Amadou BAH, Aissata DIALLO, Hamsatou CISSE-KODIO, Nagou TOLO, Ibrahim DOLLO, Tako BALLO, Niaboula KONE, Tiounkani THERA, Daouda Kassoum MINTA.
Objectives: This study investigates the residual risk of mother-to-child transmission (MTCT) of HIV among women living with HIV who are on sustained antiretroviral therapy.
Methodology: This retrospective observational cohort study analysed the medical records of HIV-positive women receiving highly active antiretroviral therapy (HAART), who were followed between 2019 January 1 and December 31, at Kati University Hospital in the Koulikoro region of Mali.
Results: Among the 996 people living with HIV (PLHIV) included in the cohort, 480 were women (48.19%). Of these, 52 (10.8%) became pregnant, with 30 pregnancies occurring during the study period. 21 (70%) had an undetectable viral load and CD4 cell counts were below 350/mm³ in 5 cases. By the end of pregnancy, 29 women delivered live new-borns, including 2 infants with low birth weight (2/29; 7%), 3 cases of prematurity and one neonatal death was recorded. After 2 years, 3 children (10.34%) were infected by HIV and one child had died. All children infected by HIV were from mothers with virological failure and had not received appropriate prophylaxis.
Conclusion: This study demonstrates that the goal of eliminating mother-to-child transmission of HIV was not achieved in this hospital.
