Langerhans Cell Histiocytosis: A Case Report
Sara Fonseca, Tatiana Moreira, Diana Simões, Maria Fátima Ferreira, Irene Carvalho.
Langerhans cell histiocytosis is a rare disease characterized by clonal proliferation of dendritic cells. Diagnosis can be difficult due to heterogeneity of clinical manifestations, affecting several organs and/or systems. We report the case of a 9-month-year-old boy who is referenced to our center due to anemia and iron deficiency. The clinical presentation with exuberant skin manifestations and persistent/recurrent infections raised the suspicion of Langerhans cell histiocytosis, confirmed with positive immunoreactivity of bone marrow cells for CD1a and protein S100. We highlight the importance of detailed clinical history in the diagnosis of Langerhans cell histiocytosis and the importance of an early diagnosisView pdf