Novel Eco-Friendly Spectrophotometric Estimation of Guaifenesin in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
Nief Rahman Ahmad, Ghfran Naif Rahman.
A simple, precise, accurate, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of guaifenesin in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 222 nm in water. Beer’s law was obeyed in the range of 2-40μg/ ml, with molar absorptivity of 0.75 ×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.4%, and accuracy (average recovery %) was 100 ± 1.0. No interference was observed from common excipients and additives often accompany with guaifenesin in pharmaceutical preparations. The method was successfully applied to the determination of guaifenesin in some pharmaceutical formulations (Syrups and Tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of guaifenesin in true samples. Application to content uniformity testing.
